Endocrine Abstracts

Background: Cystic fibrosis is an autosomal recessive disease characterised by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The mutations alter fluid secretion in the lungs and digestive systems and the vast majority of patients die from pulmonary disease. CF-related diabetes (CFRD) is the most significant co-morbidity for patients with CF and accelerates lung decline. Recent evidence from animal and cell models has implicated a role for CF...